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Effects of Stress:
What Happens When We Feel Stressed?


In those moments of being really stressed out, few of us stop to think about the effects of stress on our bodies. But if we're stressed out all the time, and starting to feel crummy, we might start to wonder just how all these physiological changes brought about by stress affect our health over time.

The news is not good. As if the subjective experience of being stressed out were not enough, over time, stress wreaks major havoc on our health. To understand how, we have to first understand how stress works.

So what exactly happens to us when we feel stressed?

Stress starts when we perceive a threat of some sort. In response, our bodies get ready to defend against the threat so that we survive it. This means speeding communication throughout the body, making sure plenty of energy is available, turning off all unnecessary tasks, and reducing our sensitivity to pain.

Collectively, these changes are known as the "fight or flight" response. To get them done, the body utilizes a series of complex interactions among the brain's hypothalamus, the pituitary gland, and the adrenal glands.

The "fight or flight" response

Here's how it works. First, the stressful stimulus is transmitted from our senses to the brain stem. The route of transmission through the hypothalamus (on the upper part of the brain stem) stimulates faster processing of noradrenaline.

Noradrenaline is a neurotransmitter that speeds communication between brain cells. This makes us more alert and aware. The extra noradrenaline also triggers the sympathetic region of the autonomic nervous system to tell the adrenal glands to begin releasing both adrenaline and noradrenaline.

Raised levels of adrenaline and noradrenaline in turn tell the pancreas to release a hormone that raises our blood sugar level.

Meanwhile, the hypothalamus starts talking to the pituitary gland, telling it to release another hormone that tells the adrenal glands to release cortisol, also known as the "stress hormone." Cortisol plays a big role in the body's stress response. It increases blood pressure and blood sugar, reduces excretion of water, stimulates secretion of gastric acid, reduces immune system response, and, in conjunction with adrenaline, helps the brain form memories of short-term emotional events.

The hypothalamus also causes the pituitary to release hormones that suppress the reproductive system, make us retain water, and stimulate the body to release endorphins and enkephalins, which act as pain suppressors.

What does "fight or flight" do to our bodies?

These are the physiological effects of stress on our bodies that result from all this:

  • Heart speeds up
  • Lungs work harder
  • Digestion slows down
  • Blood vessels constrict in most of body
  • Blood vessels in muscles dilate
  • Stored fat and glucose released to muscles
  • Immune response slows
  • Tears and salivation stop
  • Pupils dilate
  • Bladder relaxes
  • Colon evacuates
  • Erection inhibited
  • Reflexes speed up
  • Loss of peripheral vision
  • Hearing becomes focused
  • Skin pales and/or flushes
  • Body shakes

  • We evolved the "fight or flight" response to stress because earlier in our evolutionary history, the kinds of dangers we faced tended to be short-term, acute, physical threats like predators, accidents, and other emergencies. We'd perceive a threat, our bodies would become primed for self-defense or escape, we'd fight or flee the threat, and when the threat had passed, we'd feel exhausted and need to rest and recover from the effects of stress and exertion.

    Since these acute physical threats were relatively few and far between, we would not have to run our bodies this hard for an extended period of time, and would have adequate time to recover completely.

    Modern stress is different, but we respond the same

    stress management worker
    The modern world we live in (urban, industrialized, technologized) has only existed for the last few centuries. The big change for us stress-wise is in the nature of the threats we face.

    Nowadays, we are less likely to face short-term physical threats and more likely to face longer-term social and psychological ones.

    Evolutionarily speaking, a few hundred years isn't enough time for us to have developed stress responses that are more appropriate for modern stress.

    That's really the crux of the problem.

    Because our bodies can't distinguish whether the thing that is stressing us out is a physical threat or a social or psychological one, we get the "fight or flight" response regardless.

    If the threat is not someone attacking you but a looming work deadline, you're not going to punch someone or run for your life (though you may certainly feel like it!). Instead, you sit at your desk for hours, keyed up for action you never take. Physiologically speaking, the effects of stress leave you "all dressed up with nowhere to go."

    Once we are undergoing a "fight or flight" response, but not actually fighting or fleeing, we may react to the effects of stress by becoming angry or argumentative. This can be seen as a modern manifestation of "fight." On the other hand, we may withdraw from others, watch television, or turn to alcohol, nicotine, or other drugs to relax, the modern version of "flight."

    Whether a person chooses to fight or flee may also be a matter of gender. Studies indicate that men are more likely to respond to the effects of stress by putting up a fight, whereas women are more likely to try to escape from or defuse the threatening situation. Women also become protective of their children and seek help from others when under threat.

    In any case, today's "fight or flight" response is not often followed by physical action, so the effects of stress linger. Because you don't discharge them by fighting or running, all the hormones that have been activated continue to sit in your body, affecting your heart rate, blood pressure, blood sugar, digestion, immune system, and all the rest, until they gradually dissipate and you return to a relaxed state.

    Modern stress lasts longer

    If you return to a relaxed state. Modern stressors tend to be longer term. When you experience heightened stress levels over an extended period of time, your body can remain in a state of physiological arousal more and more of the time, rarely returning all the way to its normal, balanced state.

    Over time, all this readiness wears your body down. We're not designed to run in emergency mode all the time. This is where the connection between stress and health comes into play. After extended exposure to stress, you can begin to experience nausea, dizziness, chest pain, digestive problems, headaches, insomnia, aches and pains, diarrhea, constipation, anxiety, more frequent colds, even loss of sex drive.

    Even more troublesome, other effects of stress are to exacerbate existing medical conditions, and cause or contribute to new ones.

    Managing "fight or flight" for better health

    Some day, humans may evolve more effective responses to social and psychological stressors. Then, our bodies may have different and better ways of preparing us to cope with modern stress than the "fight or flight" response.

    Unfortunately, that's not going to help today's humans. But there are things we can do to better manage the host of changes brought about by the "fight or flight" response. Good nutrition, proper rest, exercise, and learning to relax can all help our bodies recover sooner from the effects of stress.

    Even better, by paying attention to how we feel, we can learn to recognize the beginnings of a "fight or flight" response, which can allow us to take steps to defuse it early.

    And when a car swerves into our lane, or a stack of boxes starts to fall on us, we can still thank Mother Nature that our bodies know how to instantaneously prepare us to react quickly.


    Photo by alancleaver_2000 via Flickr, used under a Creative Commons license.






    Stress News


    It's National Stress Awareness Month!

    Did you know April is National Stress Awareness Month? Since 1992, thanks to the Health Resource Network, Americans have a month to focus on the problem of stress and how to better handle it. According to HRN's website, health care professionals and people who promote health are disseminating information and leading forums, discussion groups, and community events to raise awareness and educate the public about stress.

    There's also a National Stress Awareness Day -- April 16, the day after taxes are due. Which may make it a great occasion on which to reflect about starting your taxes earlier next year.


    Gene Reduces Vulnerability to Stress

    If you handle stress well, you may have mom and dad to thank. UCLA researchers studying the IL6 gene and the biochemical pathway that triggers it have discovered that people who have a less common variant of the gene may be more able to withstand life's stressful events. The IL6 gene controls the body's immune response, causing inflammation when activated during the body's "fight or flight" response to stress. The most common variant of IL6 is associated with cardiovascular disease and cancer, and people with this variant have an increased risk of death for 11 years after suffering a stressful life event severe enough to trigger depression. But a less common version of IL6 lacks the pathway for stress to trigger it, resulting in no increased risk of death following major stress for those who carry it. The study will appear in an upcoming issue of the journal Proceedings of the National Academy of Sciences.

    (UCLA News Release, 2/10)


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    Stress During Learning Affects Ability to Remember Stuff

    If you want to retain what you learn, don't try to learn it when you're under stress. German researchers subjected people to stress (immersing their hands in cold water -- ouch!) while they were learning words. During recall and recognition tests 24 hours later, the numb-handed people performed less well than control subjects who were not exposed to stress during the learning exercise.

    (Journal of Neurobiology of Learning and Memory, 2/10)


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